Metal-mediated peptide assembly: use of metal coordination to change the oligomerization state of an alpha-helical coiled-coil.
نویسندگان
چکیده
Metal coordination is used to alter the oligomerization state of a designed peptide structure. The 30-residue polypeptide AQ-Pal14Pal21contains two metal-binding 4-pyridylalanine (Pal) residues on its solvent-exposed surface and exists as a very stable two-stranded alpha-helical coiled-coil. Upon the addition of Pt(en)(NO3)2, a significant conformational change to a metal-bridged, four-helix bundle is seen.
منابع مشابه
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عنوان ژورنال:
- Inorganic chemistry
دوره 46 17 شماره
صفحات -
تاریخ انتشار 2007